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[摘 要] 目的 探讨子宫颈小细胞癌的临床病理特征和预后分析.方法 回顾性分析2013年12月—2015年12月该院肿瘤科收治的18例子宫颈小细胞癌（SCCC）患者的临床资料,总结其年龄、症状、病情FIGO分期、肿瘤大小及预后,采用免疫组化SP法检测Syn、CK、CgA、CD56、EMA、NSE、TTF-1、Ki-67、S100的表达.结果 所有18例患者中,年齡27～71岁,平均年龄（40.2±5.3）岁；16例表现为宫颈接触性出血或不规则 流血,2例表现为月经不规则伴经期延长,妇科检查发现宫颈赘生物；ⅠB1期8例、ⅠB2期5例、ⅡA2期2例、ⅢB期2例、ⅣB期1例；组织学特征为瘤细胞呈圆形或短梭形,大小及形态较一致,呈不规则巢片状分布,细胞质少,核深染,核仁不明显,多见核分裂象；15例为单纯宫颈小细胞癌,2例合并中分化腺癌,1例合并宫颈高级别上皮内瘤变；免疫组化中,NSE 100.00%,CK 100.00%,EMA 88.89%,Syn 94.44%,CD 56 72.22%,CgA 77.78%,TTF-1 33.33%,S100 11.11%,Ki-67 70%～90%；肿瘤大小在1.5～6 cm,11例患者于2年内死亡.结论 SCCC为神经内分泌癌,是高度恶性肿瘤,预后极差,免疫组化对该病的诊断有一定指导意义.
[关键词] 子宫颈小细胞癌；临床病理特征；预后观察
[中图分类号] R737.33 [文献标识码] A [文章编号] 1674-0742（2017）04（c）-0044-03
[Abstract] Objective To study the clinical pathological features and prognosis analysis of small cell carcinoma of cervix. Methods 18 cases of patients with SCCC admitted and treated in our hospital from December 2013 to December 2015 were selected and the age, symptom, disease FIGO staging, tumor size and prognosis were summarized and the expressions of Syn, CK, CgA, CD56, EMA, NSE,TTF-1, Ki-67,S100 were tested by the s-p immunohistochemical method. Results Of the 18 cases of patients, the age was between 27 to 71, and the average age was（40.2±5.3）, and 16 cases were with cervix contact bleeding or irregular vaginal bleeding and 2 cases were with irregular menstruation with prolonged menstrual bleeding, and the gynecological examination showed that cervical neoplasms, 8 cases in the ⅠB1 stage, 5 cases in the ⅠB2 stage, 2 cases in the ⅡA2 stage, 2 cases in the ⅢB stage and 1 case in the ⅣB stage, and the histological characteristics were oncocyte in round or ellipse shapes, and the size and shape are consistent, showing the irregular nest with few cytoplasm and unobvious nucleolus, 15 cases were with simple small cell carcinoma of cervix, 2 cases were with moderate differentiated adenocarcinoma and 1 case with high-grade intraepithelial neoplasia, in the immunohistochemistry,NSE 100.00%,CK 100.00%,EMA 88.89%,Syn 94.44%,CD 56 72.22%,CgA 77.78%,TTF-1 33.33%,S100 11.11%,Ki-67 70%～90%, and the tumor size was 1.5～6 cm, and 11 cases died in two years. Conclusion SCCC is the neuroendocrine carcinoma and a severe malignant tumor with bad prognosis, and immunohistochemistry is of a certain guidance significance to the diagnosis of the disease.
[Key words] Small cell carcinoma of cervix； Clinical pathological features； Observation on prognosis
子宫颈小细胞癌（SCCC）为临床较为少见的子宫颈原发肿瘤,属于神经内分泌癌,恶性程度高,侵袭性高,是高危妇科肿瘤.早期死亡率较高,5年生存率仅为14%～39%[1],且大部分患者在确诊时已出现盆腔转移或远处转移,治疗效果较差.临床对SCCC的研究不如其他类型子宫颈癌完善,因此积极探寻子宫颈小细胞癌的临床病理特征和预后对临床的治疗有重要的指导意义[2].该研究分析2013年12月—2015年12月该院肿瘤科收治的18例SCCC的临床资料,进一步探讨其病理特征及预后,现报道如下.
结论：关于对写作临床病理论文范文与课题研究的大学硕士、相关本科毕业论文临床病理学就业前景论文开题报告范文和相关文献综述及职称论文参考文献资料下载有帮助。
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