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关于颈动脉论文范文写作 血清LDL—C、FIB、颈动脉斑块预测TIA后脑梗死发生价值相关论文写作资料

主题:颈动脉论文写作 时间:2024-01-04

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颈动脉论文参考文献 心理c证论文c类刊物c刊论文发表c类期刊

【摘 要】 目的 分析血清低密度脂蛋白膽固醇(LDL-C)、纤维蛋白原(FIB)、颈动脉斑块预测短暂性脑缺血发作(TIA)后脑梗死发生的价值.方法 100例TIA患者, 根据是否发生脑梗死将其分为脑梗死组和未脑梗死组, 每组50例.对两组患者血清LDL-C、FIB、颈动脉斑块情况详细记录, 比较其差异;并进行Essen评分, 通过计算ROC曲线下面积, 对比各项指标预测TIA后脑梗死发生的价值.

结果 脑梗死组患者的血清LDL-C水平为(5.23±1.20)mmol/L, 明显高于未脑梗死组的(2.24±0.80)mmol/L,

差异具有统计学意义(P<0.05).脑梗死组患者的FIB水平为(3.50±1.20)g/L, 明显高于未脑梗死组的(2.21±0.85)g/L, 差异具有统计学意义(P<0.05).脑梗死组斑块厚度(4.28±1.02)mm明显高于未脑梗死组(2.02±0.56)mm, 且易损斑块及稳定斑块数量明显多于未脑梗死组, 差异具有统计学意义(P<0.05).Essen+LDL-C、Essen+FIB、Essen+颈动脉斑块、Essen+LDL-C+FIB+颈动脉斑块评分法的ROC曲线下面积(95%CI)分别为0.771、0.667、0.715、0.805, 四种ROC曲线下面积与参考线下面积0.5比较差异具有统计学意义(P<0.05).经分析各单项指标评分法中, Essen+LDL-C在TIA后脑梗死评估中价值最高, Essen+FIB、Essen+颈动脉斑块相较Essen+LDL-C在早期脑梗死风险评估的价值不明显.结论 通过测量血清LDL-C、FIB水平以及颈动脉斑块情况对TIA后脑梗死风险做出预判, 其中LDL-C的价值最高, 而血清FIB及颈动脉斑块情况的预测价值尚需进一步研究对比, 临床上可进行联合分析, 可为临床医师分辨出高风险患者, 便于提前做出预防措施, 为此类患者的预防和治疗提供依据.

【关键词】 短暂性脑缺血发作;脑梗死;低密度脂蛋白胆固醇;纤维蛋白原;颈动脉斑块

DOI:10.14163/j.cnki.11-5547/r.2018.01.010

【Abstract】 Objective To analyze the value of l ow density lipoprotein cholesterol (LDL-C), fibrinogen (FIB) and carotid plaque in predicting the occurrence of cerebral infarction after transient ischemic attack (TIA). Methods A total of 100 TIA patients were divided by occurrence of cerebral infarction in cerebral infarction group and non-cerebral infarction group, with 50 cases in each group. The serum LDL-C, FIB and carotid plaques in two groups were recorded in detail, and their differences were compared. The value of cerebral infarction after TIA predicted by indicators were compared by the area under the ROC curve and Essen score. Results Cerebral infarction group had obviously higher serum LDL-C level as (5.23±1.20) mmol/L than (2.24±0.80) mmol/L

in non-cerebral infarction group, and the difference was statistically significant (P<0.05). Cerebral infarction group had obviously higher FIB level as (3.50±1.20) g/L than (2.21±0.85) g/L in non-cerebral infarction group, and the difference was statistically significant (P<0.05). Cerebral infarction group had obviously higher plaque thickness as (4.28±1.02) mm than (2.02±0.56) mm in non-cerebral infarction group, and obviously more number of vulnerable plaque and stable plaque than non-cerebral infarction group. Their difference was statistically significant (P<0.05). The area under the ROC curve (95%CI) of Essen+LDL-C, Essen+FIB and Essen+ carotid plaque and Essen+LDL-C+FIB+ carotid plaque score was 0.771, 0.667, 0.715 and 0.805 respectively. There was statistically significant difference in area under the four ROC curves and reference line area 0.5 (P<0.05). After analyzing each index scoring system, Essen+LDL-C was of the highest value in the evaluation of cerebral infarction after TIA, and the value of Essen+FIB and Essen+ carotid plaques was not significant in evaluating the risk of early cerebral infarction comparing with Essen+LDL-C. Conclusion The risk of cerebral infarction after TIA is predicted by measuring serum levels of LDL-C, FIB and carotid plaques. The value of LDL-C is the highest, while the predictive value of serum FIB and carotid plaques is still need further research and comparison. Combined analysis can be used for clinicians to identify high-risk patients and make preventive measures in advance, so as to provide evidence for prevention and treatment of such patients.

结论:适合颈动脉论文写作的大学硕士及相关本科毕业论文,相关颈动脉班块开题报告范文和学术职称论文参考文献下载。

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