MMP—9、CDK8和VEGF—C的表达和宫颈癌临床病理特点的关系,本文关于临床病理论文范文,可以做为相关论文参考文献,与写作提纲思路参考。
临床病理论文参考文献：
【摘 要】 目的 探討基质金属蛋白酶9（MMP-9）、细胞周期蛋白依赖性蛋白激酶8（CDK8）和血管内皮生长因子C（VEGF-C）在宫颈癌组织中的表达及临床意义.方法 应用二步法免疫组织化学染色对70例宫颈癌组织进行MMP-9、CDK8及VEGF-C蛋白检测, 观察三者表达情况及其表达与临床病理特征的关系, 并分析宫颈癌组织MMP-9表达与CDK8、VEGF-C表达的关系.结果 MMP-9、CDK8、VEGF-C在临床分期Ⅲ期的阳性表达高于Ⅱ期, 有淋巴转移者的阳性表达高于无淋巴转移者, 宫颈浸润深度≥2/3者的阳性表达高于深度<2/3者, 组织分化低的阳性表达高于高、中分化, 差异均具有统计学意义（P<0.05）.宫颈癌组织中MMP-9与CDK8表达呈正相关（rs=0.518, P<0.05）, MMP-9与VEGF-C表达呈正相关（rs=0.657, P<0.05）.结论 MMP-9、CDK8和VEGF-C的过表达促进宫颈癌的浸润转移, 具有正协同作用.联合检测MMP-9、CDK8和VEGF-C蛋白可作为预测宫颈癌的浸润转移及评价患者预后的生物学指标.
【关键词】 宫颈癌；基质金属蛋白酶9；细胞周期蛋白依赖性蛋白激酶8；血管内皮生长因子C；免疫组织化学
DOI：10.14163/j.cnki.11-5547/r.2017.25.004
【Abstract】 Objective To investigate the expression of matrix metalloproteinase-9 （MMP-9）, cyclin-dependent kinases-8 （CDK8） and vascular endothelial growth factor-C （VEGF-C） in cervical cancer tissue and its clinical significance. Methods The expression of MMP-9, CDK8 and VEGF-C in 70 cases of cervical cancer was detected by two-step immunohistochemical staining. The relationship between the expression of MMP-9, CDK8 and VEGF-C was observed and the expression of MMP-9 was analyzed. CDK8, VEGF-C expression. Observation were made on expressio of the above three proteins and its correlation with clinicopathological features, and analysis was made on correlation between the expression of MMP-9 and the expression of CDK8 and VEGF-C in cervical cancer. Results MMP-9, CDK8, VEGF-C positive expression in clinical stage Ⅲ was higher than that in stage Ⅱ, the positive expression lymphatic metastasis was higher than those without lymph node metastasis, the positive expression of infiltration depth ≥2/3 was higher than those of the cervical depth <2/3, and the positive expression of low tissue differentiation was higher than that of middle-high differentiation. Their difference had statistical significance （P<0.05）. The expression of MMP-9 was positively correlated with the expression of CDK8 in cervical cancer （rs=0.518, P<0.05）, and the expression of MMP-9 was positively correlated with VEGF-C （rs=0.657, P<0.05）. Conclusion The overexpression of MMP-9, CDK8 and VEGF-C promotes the invasion and metastasis of cervical cancer and it has synergistic effect. Combined detection of MMP-9, CDK8 and VEGF-C proteins can be used as a biological marker to predict the invasion and metastasis of cervical cancer and evaluate the prognosis of cervical cancer.
【Key words】 Cervical cancer； Matrix metalloproteinase-9； Cyclin-dependent kinases-8； Vascular endothelial growth factor-C； Immunohistochemistry
结论：适合临床病理论文写作的大学硕士及相关本科毕业论文，相关临床病理开题报告范文和学术职称论文参考文献下载。
专题9语言表达准确、鲜明、生动
【考点阐释·技法点拨】纵观近几年来全国各地的高考试题，这个知识点几乎年年考，分值3～6分。就考查方式而言，多是以主观题的形式来考查，也有个别省。
微博动员、维权倡议和记者利益表达机制
摘要 本文以一起记者被打事件为例，分析了推动维权活动展开的两个相互交织的因素——微博与意见领袖，并探讨新媒体环境中记者维权倡议和利益表达的实践空。
C罗、穆里尼奥以与他们背后的空壳公司
他们都是赫赫有名的体坛精英，不过说到跟税务局打交道，克里斯蒂亚诺·罗纳尔多（以下简称C罗）和何塞·穆里尼奥同样也是一把好手：他们都利用设在加勒比。
C罗、梅西垄断FIFA金球奖背后的品牌大PK
1月13日凌晨，2014国际足联年度颁奖庆典在苏黎世举行，足坛各项年度大奖得以宣布。C罗凭借37 66%的得票率赢得FIFA金球奖，这是他继20。